MONTREAL, April 20, 2017 – Replicor Inc., a privately held biopharmaceutical company targeting a cure for chronic HBV and HDV infection, today disclosed significant new data on NAP activity in HBV and HDV infections at the European Association for the Study of the Liver (EASL) 2017 annual meeting held April 19-23, 2017 in Amsterdam, The Netherlands.
Updates in the REP 301 (HBV/HDV coinfection) and REP 401 (HBV infection) studies demonstrated important advances:
“The notion that almost all circulating HBsAg is derived from integration has important therapeutic implications.” said CSO Dr. Andrew Vaillant, “As the primary immunosuppressive agent in HBV and HDV infections, HBsAg removal will be critical. It’s very likely that new investigational agents with other antiviral mechanisms will still require agents directly targeting HBsAg release like NAPs in order to achieve a high rate of functional control.” Dr. Bazinet, CEO, added “our continually expanding clinical data continues to demonstrate that significant rates of functional control of HBV and HDV can be achieved with currently approved drugs and NAPs.”
Deep sequencing of HBsAg in the previous REP 102 study showed no selection pressure with REP 2139, further validating the serum HBsAg response to NAP therapy (Poster THU-155). A recently developed tissue culture system now reproduces for the first time the post-entry effects of NAPs on secretion of HBV particles observed preclinically and clinically (Poster THU-156).
Dr. Vaillant remarked, “The ability to model the post-entry effects of NAPs in tissue culture is the culmination of more than 6 years of work which including various collaborators worldwide. With this tool finally in place, the host mechanisms targeted by NAPs can now begin to be explored.
Replicor is a privately held biopharmaceutical company with the most advanced clinical data in the development of the cure for HBV and HDV. The company is dedicated to accelerating the development of an effective treatment for patients with HBV and HBV/HDV infection. For further information about Replicor please visit our website at www.replicor.com