Publications

Peer Reviewed Publications on Replicor's NAP Technology

Nucleic acid-based polymers effective against hepatitis B Virus infection in patients don’t harbor immunostimulatory properties in primary isolated liver cells.

Real CI, Werner M, Paul A, Gerken G, Schlaak JF, Vaillant A, Broering B, Sci. Reports 7: 43838

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Nucleic acid polymers: Broad spectrum antiviral activity, antiviral mechanisms and optimization for the treatment of hepatitis B and hepatitis D infection. Vaillant A. Antiviral Research 2016 133: 32-40.

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Safety and Efficacy of Nucleic Acid Polymers in Monotherapy and Combined with Immunotherapy in Treatment-Naive Bangladeshi Patients with HBeAg+ Chronic Hepatitis B Infection. Al-Mahtab M, Bazinet M, Vaillant A. PLOS ONE 2016 11: e0156667

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Therapeutic Antiviral Effect of the Nucleic Acid Polymer REP 2055 against Persistent Duck Hepatitis B Virus Infection. Noordeen F, Scougall CA, Grosse A, Qiao Q, Ajilian BB, Reache-Miller G, Finnie J, Werner M, Broering R, Schlaak J, Vaillant A, Jilbert AR.  PLOS ONE 10: e0140909.

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Nucleic acid polymers prevent the establishment of duck hepatitis B virus infection in vivo. Noordeen F, Vaillant A, Jilbert AR. Antimicrob Agents Chemother. 2013 57:5299-5306.

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Nucleic acid polymers inhibit duck hepatitis B virus infection in vitro. Noordeen F, Vaillant A, Jilbert AR. Antimicrob Agents Chemother. 2013 57:5291-5298.
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Amphipathic DNA polymers exhibit antiviral activity against systemic murine Cytomegalovirus infection. Cardin RD, Bravo FJ, Sewell AP, Cummins J, Flamand L, Juteau JM, Bernstein DI, Vaillant A. Virology Journal 2009, 6:214.
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Amphipathic DNA polymers inhibit hepatitis C virus infection by blocking viral entry. Matsumura T, Hu Z, Kato T, Dreux M, Zhang YY, Imamura M, Hiraga N, Juteau JM, Cosset FL, Chayama K, Vaillant A, Liang TJ. Gastroenterology. 2009 Aug;137(2):673-81.
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Amphipathic DNA polymers exhibit antiherpetic activity in vitro and in vivo. Bernstein DI, Goyette N, Cardin R, Kern ER, Boivin G, Ireland J, Juteau JM, Vaillant A. Antimicrob Agents Chemother. 2008 Aug;52(8):2727-33
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Amphipathic DNA polymers are candidate vaginal microbicides and block herpes simplex virus binding, entry and viral gene expression. Guzman EM, Cheshenko N, Shende V, Keller MJ, Goyette N, Juteau JM, Boivin G, Vaillant A, Herold BC. Antivir Ther. 2007;12(8):1147-56. Erratum in: Antivir Ther. 2008;13(2):335.
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Inhibition of cellular entry of lymphocytic choriomeningitis virus by amphipathic DNA polymers. Lee AM, Rojek JM, Gundersen A, Ströher U, Juteau JM, Vaillant A, Kunz S. Virology. 2008 Mar 1;372(1):107-17
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Phosphorothioate oligonucleotides inhibit human immunodeficiency virus type 1 fusion by blocking gp41 core formation. Vaillant A, Juteau JM, Lu H, Liu S, Lackman-Smith C, Ptak R, Jiang S. Antimicrob Agents Chemother. 2006 Apr;50(4):1393-401.
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